Relevoderm Assists With Hyperpigmentation Including Melasma

Melasma is an acquired disorder of symmetrical hyperpigmentation. Appearing as light brown to dark patches on the forehead, malar areas, nose, and chin. Both topical and oral forms of glutathione were well tolerated for all types of skin. It is better to use topical form in recent lesions, epidermal melasma type and in skin type III. It is advised to use oral form in old lesions, mixed melasma type, and skin type IV.

Dermal melasma type may need combination of both topical and oral glutathione. Duration of glutathione treatment must be not less than 10 weeks in topical form and not less than 4 weeks in oral form.

While there is no published data for intravenous glutathione, the results of the three randomized controlled trials mentioned above have provided grade Ib and 2b evidence in favours of the skin-lightening effects of topical and oral glutathione, with no significant adverse effects [Table 1].

Evidence-based efficacy of ORAL glutathione as an oral-lightening agent

A randomized, double-blind, two-arm, placebo-controlled study conducted in the Thai population studied the effect of orally administered glutathione on the skin melanin index in sixty healthy medical students [Table 1]. The subjects were randomized to receive glutathione capsules in a dose of 500 mg/day in two divided doses, or placebo for four weeks. The primary endpoint studied was the reduction of melanin indices at six different sites. At four weeks, the melanin indices decreased consistently at all six sites in the glutathione group. There was a statistically significant reduction at two sites in the placebo group, namely the right side of the face and the sun-exposed left forearm. The tolerance to glutathione was excellent.

This study was the first to demonstrate the beneficial effects of oral glutathione in skin lightening.

Glutathione as a skin whitening agent: Facts, myths, evidence and controversies Sidharth Sonthalia1, Deepashree Daulatabad2 , Rashmi Sarkar3 , 1 Skinnocence: The Skin Clinic, Gurgaon, Haryana, India 2 Department of Dermatology and STD, UCMS and GTB Hospital, New Delhi, India 3 Department of Dermatology and STD, MAMC and LN Hospital, New Delhi, India

From this study, it could be concluded that glutathione is safe, inexpensive and effective whitening agent in the treatment of melasma. Both topical and oral forms of glutathione were well tolerated for all types of skin. It is better to use topical form in recent lesions, epidermal melasma type and in skin type III. It is advised to use oral form in old lesions, mixed melasma type, and skin type IV. Dermal melasma type may need combination of both topical and oral glutathione. Duration of glutathione treatment must be not less than 10 weeks in topical form and not less than 4 weeks in oral form.

References

Evaluation of the Efficacy and Safety of Topical and Oral Glutathione in Treatment of Melasma AL-SHAIMAA A. FARAHAT, M.Sc.*; LAMIA H. EL-GARHY, M.D.*; NAGEH A. EL-MAHDY, M.D.** and BASMA M. ALI, M.D.* The Departments of Dermatology & Venereology, Faculty of Medicine* and Pharmacology, Faculty of Pharmacy**, Tanta University, Tanta, Egypt .